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Research “Game-changer”: Spike Protein Increases Heart Attacks and Destroys Immune ​System

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By Mike Whitney

Source: Global Research

“This is really a technology designed to poison people, there’s really no two-ways about it.” Dr. Michael Palmer on mRNA vaccines

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Question– Does the Covid-19 vaccine cause heart attacks?

Answer– It does, and researchers are closer to understanding the mechanism that triggers those events.

Question– How can I be sure you’re telling the truth?

Answer– Well, for starters, there’s a research paper that appeared recently in the prestigious Circulation magazine that draws the same conclusion. Here’s an excerpt from the paper:

“We conclude that the mRNA vacs dramatically increase inflammation on the endothelium (layer of cells lining the blood vessels) and T cell infiltration of cardiac muscle and may account for the observations of increased thrombosis (clotting), cardiomyopathy, (a group of diseases that affect the heart muscle) and other vascular events following vaccination.” (“Abstract 10712: Mrna COVID Vaccines Dramatically Increase Endothelial Inflammatory Markers and ACS Risk as Measured by the PULS Cardiac Test: a Warning”, Circulation)

It’s actually quite rare for researchers to be so blunt in their analysis, but there it is in black and white. As you can see, they didn’t pull their punches. Here’s how Alex Berenson summed it up on his blogsite at Substack:

“A new study of 566 patients who received either the Pfizer or Moderna vaccines shows that signs of cardiovascular damage soared following the shots. The risk of heart attacks or other severe coronary problems more than doubled months after the vaccines were administered, based on changes in markers of inflammation and other cell damage. Patients had a 1 in 4 risk for severe problems after the vaccines, compared to 1 in 9 before. (“If you like heart problems, you’ll love the Pfizer and Moderna Covid vaccines”, Alex Berenson, Substack)

“Doubled”? “The risk of heart attacks.. more than doubled” after vaccination?

Apparently, so. No wonder cardiologist Dr. Aseem Malhotra is so flabbergasted. Here’s what he said in a recent interview:

“Extraordinary, disturbing and upsetting. We now have evidence of a plausible biological mechanism of how mRNA vaccine may be contributing to increased cardiac events. The abstract is published in the highest impact cardiology journal so we must take these findings very seriously.”

Indeed, we must, but our public health experts continue to pretend that nothing has changed, even though more and more professionals continue to speak out. Here’s Malhotra again:

“I have alot of interaction with the cardiology community across the UK, and anecdotally, I have been told by colleagues that they are seeing younger and younger people coming in with heart attacks…. Now since July, there’s been at least 10,000 non-covid deaths, and most of those have been driven by circulatory disease, in other words, heart attack and stroke. And there’s been a 30% increase in deaths at home, often because of cardiac arrest…. (So) The signal is quite strong… This needs to be investigated… And I think it is high-time that policymakers around the world put an end to the mandates, because –if this signal is correct– then history will not be on their side and the public will not forgive them for it.”

Shocking, right? And what’s more shocking is the media’s response which is aimed at concealing the fact that these toxic injections pose a clear threat to the lives of millions. Is that overstating the case?

No, not at all.

So, what conclusions can we draw from this new research? What is the science telling us?

It’s telling us that the vaccine can reduce the flow of blood to the heart, damage heart tissue, and greatly increase the risk of a heart attack. The authors are telling readers point-blank that the vaccine can either kill or severely injure them. Can you see that?

Question– I can’t say. I haven’t read the report.

Answer– No, you haven’t, and you probably won’t either since the big news organizations and social media giants are going to make sure it never sees the light of day. But just read that one paragraph over again and try to grasp what the authors are saying. They’re saying that many people who choose to get vaccinated will either die or have years shaved off their lives. And–remember–this isn’t an opinion piece. It’s science. It’s also a straightforward repudiation of a mass vaccination campaign that is demonstrably killing people.

Question– You always exaggerate. This is just one report from one group of researchers. I could easily provide you with research that refutes your theory.

Answer– I’m sure you could, in fact there’s a small army of industry-employed propagandists (aka– “fact checkers”) who spend all their waking hours cobbling together fake news stories that do just that; discredit the science that veers even slightly from the official narrative. The truth is, the pro-vaxx disinformation campaign has been vastly more effective than the vaccine itself. I don’t think even you’d disagree with that.

Question– I do disagree with that, and I resent your characterization of the widespread support for these essential procedures as “pro-vaxx disinformation”. That is an extremely biased and ignorant statement.

Answer– Is it? In the last few weeks, we’ve produced hard evidence that a great many people who died after vaccination, died from the vaccination. We showed, for example, that two German pathology professors, Arne Burkhardt and Walter Lang, found that in five of the ten autopsies, “the two physicians rate the connection between death and vaccination as very probable, in two cases as probable.” These same doctors found that “lymphocytic myocarditis, the most common diagnosis.…(along with) autoimmune phenomena, reduction in immune capacity, acceleration of cancer growth, vascular damage “endothelitis”, vasculitis, perivasculitis and erythrocyte “clumping”.. In other words, the whole ‘dog’s breakfast’ of maladies that have been linked to the “poison-death shot”. (See full report here; “Lymphocyte riot’: Pathologists investigate deaths after Corona vaccination”, Free West Media)

These same pathologists found evidence of a “lymphocyte riot”, potentially in all tissues and organs. (Note– Lymphocytes are white blood cells in the immune system that swing into action to fight invaders or pathogen-infected cells. A “lymphocyte riot” suggests the immune system has gone crazy trying to counter the effects of billions of spike proteins located in cells in the bloodstream. As the lymphocytes are depleted, the body grows more susceptible to other infections which may explain why a large number of people are now contracting respiratory viruses in late summer.)

The autopsies provide hard evidence that the vaccines do, in fact, cause significant tissue damage. So, my question to you is this: How do you brush aside the rock-solid proof that the vaccines inflict significant injury on people who get injected? Do you need to examine the maligned corpses yourself before you change your mind and admit you’re wrong?

Question– Nothing can be deduced from just 10 autopsies. More than a billion people have been vaccinated so far, and the deaths are still within an acceptable range given the severity of the disease.

Answer– “The severity of the disease”? You mean a virus that is survived by over 99.98% of the people who catch it? You mean an infection that –according to the latest figures from Johns Hopkins– killed 351,000 in the US in 2020 which is roughly half the number of people who die from heart disease every year? And when you say: “Nothing can be deduced from just 10 autopsies”, you are very much mistaken. You can detect a pattern of vaccine-generated disease that is produced by the injection of a toxic substance (spike protein) that causes bleeding, clotting and autoimmunity even in the people who survive. “Survival” does not mean undamaged. Oh, no. And anyone who has seen the many videos of healthy athletes dropping dead on the field of play months after being jabbed, should understand that “There go I but for the grace of God.” Bottom line: If you get injected, you’re never going to know whether you’ll be struck-down without warning by a similar cardio-type event. (See: “At least 69 athletes collapse in one month, many dead”, freewestmedia.com)Lethal Injection; Frontline E.R. Doctor Gives Chilling Account of Unusual Vaccine-Induced Illness

Do you think that if these athletes knew they could die from the vaccine, they would have made the choice they did?

Question– You’re being overly dramatic. Naturally, not everyone is going to react the same to an emergency-use drug, but– on balance– the vaccines have mitigated the impact of a deadly pandemic the likes of which we haven’t seen for more than a century.

Answer– You really believe that, don’t you? Just like you really believe that Covid-19 is a totally unique and “novel” virus. If you just researched it a bit, you’d know that that theory has been thoroughly debunked. The Coronavirus isn’t new; it is an iteration of numerous other infections that have spread through the population for a least 2 decades. Take a look at this except from a research paper by the Doctors for Covid Ethics and you’ll see what I’m talking about:

“Several studies have demonstrated that circulating SARS-CoV-2-specific IgG and IgA antibodies became detectable within 1-2 weeks after application of mRNA vaccines... Rapid production of IgG and IgA always indicates a secondary, memory-type response that is elicited through re-stimulation of pre-existing immune cells…. Importantly, however, IgG rose faster than IgM, which confirms that the early IgG response was indeed of the memory type. This memory response indicates pre-existing, cross-reactive immunity due to previous infectionwith ordinary respiratory human coronavirus strains….

Memory-type responses have also been documented with respect to T-cell-mediated immunity. Overall, these findings indicate that our immune system efficiently recognizes SARS-CoV-2 as “known” even on first contact. Severe cases of the disease thus cannot be ascribed to lacking immunity. Instead, severe cases might very well be caused or aggravated by pre-existing immunity through antibody-dependent enhancement.

This study confirms the above assertion that the immune response to initial contact with SARS-CoV-2 is of the memory type. In addition, it shows that this reaction occurs with almost all individuals, and particularly also with those who experience no manifest clinical symptoms.

Conclusion– The collective findings discussed above clearly show that the benefits of vaccination are highly doubtful. In contrast, the harm the vaccines do is very well substantiated, with more than 15.000 vaccination-associated deaths now documented in the EU drug adverse events database (EudraVigilance), and over 7.000 more deaths within the UK and the US.” (“Letter to Physicians: Four New Scientific Discoveries Regarding COVID-19 Immunity and Vaccines – Implications for Safety and Efficacy”, Doctors for Covid Ethics)

Repeat: If the vast majority of people already have robust, pre-existing immunity, “then the benefits of vaccination are highly doubtful.”

​Is that a reasonable “evidence-based” conclusion? And, if it is, then shouldn’t there have been a debate on this matter before over a billion people were inoculated with an experimental substance that causes, bleeding, clotting, autoimmunity, strokes, and heart attacks? And how could it not be true, after all, if there was no pre-existing immunity in a US population of 330 million people, then the number of fatalities would be exponentially higher. Instead, after a full two years of exposure– the percentage of deaths in the US is still less than one-third of one percent, a veritable drop in the bucket. Would that be possible with a truly super-contagious “novel” virus?

No, it would not be possible, which means that Fauci and Co lied. And the reason they lied was to convince people that they’re more vulnerable than they really are. It’s just one of many fearmongering scams they used to promote the vaccine: “Get vaccinated or die”, that was the message.

Doesn’t that bother you? Doesn’t it bother you to know the government and public health authorities twisted the truth in order to dupe you into an invasive and potentially-lethal medical procedure?

Question– I think our public health officials did the best they could given the circumstances.

Answer– I think you are wrong about that. I think they have lied repeatedly in order to advance a predominantly-political agenda. But, let’s assume you’re right for a minute. Then why do they continue to ignore groundbreaking research that conflicts with their political objectives? Have you thought about that? I already mentioned the shocking report above that indicates the vaccine reduces the flow of blood to the heart and increases the risk of a heart attack. Have you heard a peep out of Fauci or Walensky about that report?

No, not a thing.

Why do you think that is? You’d assume that if Fauci had our best interests in mind, he’d use his sway with the media to spread-the-word far and wide. But, no. He’s made no effort to confirm what the research indicates; that there’s a clear link between the production of the spike protein and cardiovascular damage. He hasn’t lifted a finger in that regard, and it shows. The surge in fatalities and the sharp uptick in excess deaths in the vast number of countries that launched mass vaccination campaigns earlier in the year, are mainly circulatory deaths, that is, heart attacks, strokes and the like. The latest example of this phenom is the Netherlands which has seen a 20% spike in deaths over the previous year. Check it out:

“Last week the number of deaths was more than 20 percent higher than usual for this time of year. The Dutch Central Bureau of Statistics (CBS) reported 3 750 deaths, nearly 850 more than expected. According to the statistical office, the higher mortality can be seen in all age groups.

In the Netherlands, 85 percent of people over the age of 18 are fully vaccinated, and many had their jabs only recently. …
Dutch officials have started injecting those 80 with boosters on Thursday, weeks earlier than planned…

Based on weekly data from the Office of National Statistics (ONS) in the UK, vaccinated people under 60 are twice as likely to die as unvaccinated people. And overall deaths in Britain are far above normal.

As in Germany, Swedes also appear to die at rates 20 percent or more above normal for weeks after receiving their second Covid jab, according to data from a Swedish study.” (“Dutch deaths more than 20% higher than previous year”, Free West Media)

And this isn’t just happening in the Netherlands and Germany either. It’s happening everywhere that mass vaccination campaigns were launched earlier in the year. Now, all of those countries are seeing a sharp uptick in cardiac arrests, strokes, vascular damage and blood clots. Why? What did we do differently in 2021 than we did in the years before?

Question– Where are you going with this? I feel like you’re setting me up for something?

Answer– I am. I want you to admit that the data now supports the case for terminating the vaccination campaign immediately. That’s my main objective, to convince people that we’re on the wrong track and need to stop this madness before more people die.

Did you know that the vaccines also damage the immune system?

It’s true, the injections are immuno-suppressant which means the body is less capable of fighting off infections, viruses and diseases. Think about that for a minute. The vaccine was supposed to protect its recipients from sickness and death, instead it does the exact opposite. It prevents cells from producing the antibodies that are needed to stave-off infection. Check out this short blurb from Dr. David Bauer of Francis Crick Institute who explains what’s going on:

“So, the key message from our finding is that, we found that recipients of the Pfizer vaccine– those who have two doses– have five to six-fold lower of neutralizing antibodies. These are the “gold standard” private-security antibodies of your immune system, which block the virus from getting into your cells in the first place. So, we found that that’s less for people with two doses. We also found that for people with just one dose of the Pfizer jab, that they are less likely to have high levels of these antibodies in their blood. And perhaps most importantly, we see that the older you are, the lower your levels are likely to be, and the time since you’ve had your second jab, the longer that time goes on, the lower your levels are likely to be. So, that’s telling us that we’re probably going to need to prioritize boosters for older and more vulnerable people, coming up soon, especially if this new variant spreads.” 

6-times less neutralizing antibodies?

Yep. Like we said, the vaccine suppresses the immune system which opens a pathway to infection. Here’s how Alex Berenson summed it up in an article he posted recently on Substack:

“What the British are saying is they are now finding the vaccine interferes with your body’s innate ability after infection to produce antibodies against not just the spike protein but other pieces of the virus….

This means vaccinated people will be far more vulnerable to mutations in the spike protein EVEN AFTER THEY HAVE BEEN INFECTED AND RECOVERED ONCE...

… it probably is still more evidence the vaccines may interfere with the development of robust long-term immunity post-infection.” (“URGENT: Covid vaccines will keep you from acquiring full immunity EVEN IF YOU ARE INFECTED AND RECOVER“, Alex Berenson, Substack)

But how can that be? How can the government, the public health establishment and the drug companies push a vaccine that actually makes people more vulnerable to disease? It makes no sense, right; unless, of course, the object is to make people sicker and more likely to die? Is that what’s going on?

Indeed, it is. Here’s more from a Pfizer whistleblower:

“A former Pfizer employee, now working as a pharmaceutical marketing expert and biotech analyst, has provided evidence in a public meeting in September suggesting that Pfizer is aware that these shots can cause those vaccinated to be more prone to contracting COVID-19 and infections.

According to the whistleblower Karen Kingston, “So, when they weren’t injected, their infection rate was 1.3% and when they got injected, it was 4.34%. It went up by over 300%. They had less infection when they had no protection. So, that’s a problem.” (“VIDEO: Former Pfizer Employee Says COVID-19 Vaccine Causes Recipients to Become More Susceptible to the Virus”, Gateway Pundit)

Why isn’t this front-page news? Why is the science being suppressed? Why are the claims of credible professionals being swept under the rug, censored on social media, and brushed aside by our public health officials?

The only reasonable explanation, is that the authors of the mass vaccination campaign want to conceal the dangers of the vaccine from the public, because what they really care about is universal vaccination, making sure that all 7 billion people on Planet Earth are vaccinated come hell-or-high-water. As you can see, the science hasn’t deterred them at all. They are just as determined to implement their plan as they were on Day 1, maybe more so.

Take a look at this clip from an explosive paper that shows how the spike protein enters the nucleus of our cells causing incalculable damage to the immune system. This cutting-edge research has caused a furor in the scientific community.

“Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the coronavirus disease 2019 (COVID–19) pandemic, severely affecting public health and the global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection and directly influences the clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed and weak adaptive immune responses; however, the mechanism by which SARS–CoV–2 impedes adaptive immunity remains unclear. Here, by using an in vitro cell line, we report that the SARS–CoV–2 spike protein significantly inhibits DNA damage repair, which is required for effective V(D)J recombination in adaptive immunity.

Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site. Our findings reveal a potential molecular mechanism by which the spike protein might impede adaptive immunity and underscore the potential side effects of full-length spike-based vaccines.” (“SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro”, SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In Vitro”, mdpi.com)

What does it mean?

It means that the spike protein enters the nucleus of our cells and damages our DNA. That was not supposed to happen. The vaccine was not supposed to penetrate the inner sanctum where our genetic material is stored. Once it makes its way to the nucleus, the spike protein prevents the repair of broken DNA which, in turn, impacts the proliferation of B-cells and T-cells that are essential in the fight against infection. (Note– The spike also effects specific genes that are highly “predispositional for cancer development… so, this is clearly news of great significance that should not be taken lightly.” (See– “Spike protein inside nucleus enhancing DNA damage? – COVID-19 mRNA vaccines update 1″, youtube, 12 minutes)

Here’s how Dr. Mobeen Syed explains the effects of the spike protein on the immune system: (I transcribed this myself and apologize for any errors.)

“The spike protein enters the nucleus, and not just the spike but also the non-structural proteins end up in the nucleus as well. They do not just contaminate the DNA, but also interfere with the machinery and repair of the DNA… When our cells are dividing, there are strict mechanisms to make sure the DNA is correctly repaired, and correctly copied, otherwise the cell will become a cancer cell. We have an elaborate mechanism to repair DNA…. There are multiple mechanisms for DNA repair, because there are multiple kinds of repair… These two mechanisms are important, because these two mechanisms of repair are impaired by the spike proteins presence.… When any infection occurs, the B cells and T cells proliferate. Increasing in number, means making copies of the DNA… Proliferation itself is an important immune response. The creation of the antibodies requires functioning DNA...

What I am explaining here is that DNA break-and-repair can also be done in immune cells intentionally for the normal function of the immune system. Every B and T cell needs a variable binding sight to attach to the antigen, and to create that variation we need the DNA to randomly restructure which needs DNA break-and-repair … Imagine there are repair enzymes in our body that go to the broken DNA and fix it. Now imagine that these repair enzymes no longer go to the site of the broken DNA or even are produced? Researchers found that when the nonstructural proteins are drawn into the nucleus, then reduced proliferation of the (B and T) cells occurs… and our ability to respond to infections will not be good.” (“Spike Protein Goes to Nucleus and Impairs DNA Repair”Spike Protein Goes to Nucleus and Impairs DNA Repair”, you tube)

Imagine if someone or some group of powerful elites wanted to reduce the global population by many billions of people. And they figured the best way to achieve that objective would be to inject people with a mysterious pathogen that had been secretly developed in foreign labs for over a decade. Imagine if that lethal antigen not only triggered heart attacks, strokes and catastrophic vascular injury, but also disabled the body’s critical defense (immune) system, thus, increasing one’s susceptibility to infections, viruses and diseases by many orders of magnitude. Imagine if we saw signs that this plan was unfolding before our very eyes, from the mountain of corpses that were riddled with killer lymphocytes, to the sharp rise in excess deaths and all-cause mortality, to the unexplained surge in cardiac arrests, strokes, autoimmunity, bleeding, clotting, headaches, bruising, inflammation, heart-valve problems, brain bleeds, vascular, neurological and respiratory diseases all suspiciously linked to the initiation of a mass vaccination campaign.

Could such a thing could happen in this day and age? Could anyone be bold enough to launch a war against humanity? Is anyone capable of such evil?

Yes, they are.

Mass Vaccination Amidst A Pandemic Creates An Irrepressible Monster

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By Geert Vanden Bossche and Raúl Ilargi Meijer

Source:  The Automatic Earth

This is a open letter by a virologist named Geert Vanden Bossche. It may well be the scariest thing I’ve read on Covid19 so far. It took me a long time to edit it, there were hundreds of spelling mistakes. If any are left (no doubt), blame me.

Core: the vaccination campaigns and “measures” presently employed are the worst thing we could do: they only serve to make us weaker and the virus stronger, “turning a relatively harmless virus into a bioweapon of mass destruction” that will “wipe out large parts of our human population”.

 

Geert Vanden Bossche, DMV, PhD, independent virologist and vaccine expert, formerly employed at GAVI and The Bill & Melinda Gates Foundation.

To all authorities, scientists and experts around the world, to whom this concerns: the entire world population.

 

I am all but an anti-vaxxer. As a scientist I do not usually appeal to any platform of this kind to make a stand on vaccine-related topics. As a dedicated virologist and vaccine expert I only make an exception when health authorities allow vaccines to be administered in ways that threaten public health, most certainly when scientific evidence is being ignored. The present extremely critical situation forces me to spread this emergency call. As the unprecedented extent of human intervention in the Covid-19 pandemic is now at risk of resulting in a global catastrophe without equal, this call cannot sound loudly and strongly enough.

As stated, I am not against vaccination. On the contrary, I can assure you that each of the current vaccines have been designed, developed and manufactured by brilliant and competent scientists. However, this type of prophylactic vaccines are completely inappropriate, and even highly dangerous, when used in mass vaccination campaigns during a viral pandemic. Vaccinologists, scientists and clinicians are blinded by the positive short-term effects in individual patients, but don’t seem to bother about the disastrous consequences for global health. Unless I am scientifically proven wrong, it is difficult to understand how current human interventions will prevent circulating variants from turning into a wild monster.

Racing against the clock, I am completing my scientific manuscript, the publication of which is, unfortunately, likely to come too late given the ever increasing threat from rapidly spreading, highly infectious variants. This is why I decided to already post a summary of my findings as well as my keynote speech at the recent Vaccine Summit in Ohio on LinkedIn. Last Monday, I provided international health organizations, including the WHO, with my analysis of the current pandemic as based on scientifically informed insights in the immune biology of Covid-19. Given the level of emergency, I urged them to consider my concerns and to initiate a debate on the detrimental consequences of further ‘viral immune escape’. For those who are no experts in this field, I am attaching below a more accessible and comprehensible version of the science behind this insidious phenomenon.

While there is no time to spare, I have not received any feedback thus far. Experts and politicians have remained silent while obviously still eager to talk about relaxing infection prevention rules and ‘springtime freedom’. My statements are based on nothing else but science. They shall only be contradicted by science. While one can barely make any incorrect scientific statements without being criticized by peers, it seems like the elite of scientists who are currently advising our world leaders prefer to stay silent. Sufficient scientific evidence has been brought to the table.

Unfortunately, it remains untouched by those who have the power to act. How long can one ignore the problem when there is at present massive evidence that viral immune escape is now threatening humanity? We can hardly say we didn’t know – or were not warned. In this agonizing letter I put all of my reputation and credibility at stake. I expect from you, guardians of mankind, at least the same. It is of utmost urgency. Do open the debate. By all means: turn the tide!

The key question is: why does nobody seem to bother about viral immune escape? Let me try to explain this by means of a more easily understood phenomenon: Antimicrobial resistance. One can easily extrapolate this scourge to resistance to our self-made ‘antiviral antibiotics’. Indeed, antibodies (Abs) produced by our own immune system can be considered self-made antiviral antibiotics, regardless of whether they are part of our innate immune system (so-called ‘natural’ Abs’) or elicited in response to specific pathogens (resulting in so-called ‘acquired’ Abs). Natural Abs are not germ-specific whereas acquired Abs are specifically directed at the invading pathogen. At birth, our innate immune system is ‘unexperienced’ but well-established. It protects us from a multitude of pathogens, thereby preventing these pathogens from causing disease. As the innate immune system cannot remember the pathogens it encountered (innate immunity has no so-called ‘immunological memory’), we can only continue to rely on it provided we keep it ‘trained’ well enough. Training is achieved by regular exposure to a myriad of environmental agents, including pathogens.

However, as we age, we will increasingly face situations where our innate immunity (often called ‘the first line of immune defense’) is not strong enough to halt the pathogen at the portal of entry (mostly mucosal barriers like respiratory or intestinal epithelia). When this happens, the immune system has to rely on more specialized effectors of our immune system (i.e., antigen-specific Abs and T cells) to fight the pathogen. So, as we grow up, we increasingly mount pathogen-specific immunity, including highly specific Abs. As those have stronger affinity for the pathogen (e.g., virus) and can reach high concentrations, they can quite easily outcompete our natural Abs for binding to the pathogen/virus. It is precisely this type of highly specific, high affinity Abs that current Covid-19 vaccines are inducing. Of course, the noble purpose of these Abs is to protect us against Covid-19. So, why then should there be a major concern using these vaccines to fight Covid-19? Well, similar to the rules applying to classical antimicrobial antibiotics, it is paramount that our self-made ‘antiviral antibiotics’ are made available in sufficient concentration and are tailored at the specific features of our enemy.

This is why in case of bacterial disease it is critical to not only choose the right type of antibiotic (based on the results from an antibiogram) but to also take the antibiotic for long enough (according to the prescription). Failure to comply with these requirements is at risk of granting microbes a chance to survive and hence, may cause the disease to flare up. A very similar mechanism may also apply to viruses, especially to viruses that can easily and rapidly mutate (which is, for example, the case with Coronaviruses); when the pressure exerted by the army’s (read: population’s) immune defense starts to threaten viral replication and transmission, the virus will take on another coat so that it can no longer be easily recognized and, therefore, attacked by the host immune system. The virus is now able to escape immunity (so-called: ‘immune escape’). However, the virus can only rely on this strategy provided it still has room enough to replicate.

Viruses, in contrast to the majority of bacteria, must rely on living host cells to replicate. This is why the occurrence of ‘escape mutants’ isn’t too worrisome as long as the likelihood for these variants to rapidly find another host is quite remote. However, that’s not particularly the case during a viral pandemic! During a pandemic, the virus is spreading all over the globe with many subjects shedding and transmitting the virus (even including asymptomatic ‘carriers’). The higher the viral load, the higher the likelihood for the virus to bump into subjects who haven’t been infected yet or who were infected but didn’t develop symptoms. Unless they are sufficiently protected by their innate immune defense (through natural Abs), they will catch Covid-19 disease as they cannot rely on other, i.e., acquired Abs. It has been extensively reported, indeed, that the increase in S (spike)-specific Abs in asymptomatically infected people is rather limited and only short-lived.

Furthermore, these Abs have not achieved full maturity. The combination of viral infection on a background of suboptimal Ab maturity and concentration enables the virus to select mutations allowing it to escape the immune pressure. The selection of those mutations preferably occurs in the S protein as this is the viral protein that is responsible for viral infectiousness. As the selected mutations endow the virus with increased infectious capacity, it now becomes much easier for the virus to cause severe disease in infected subjects. The more people develop symptomatic disease, the better the virus can secure its propagation and perpetuation (people who get severe disease will shed more virus and for a longer period of time than asymptomatically infected subjects do). Unfortunately enough, the short-lived rise in S-specific Abs does, however, suffice to bypass people’s innate/natural Ab. Those are put out of business as their affinity for S is lower than the affinity of S-specific Abs.

This is to say that with an increasing rate of infection in the population, the number of subjects who get infected while experiencing a momentary increase in S-specific Abs will steadily increase. Consequently, the number of subjects who get infected while experiencing a momentary decrease in their innate immunity will increase. As a result, a steadily increasing number of subjects will become more susceptible to getting severe disease instead of showing only mild symptoms (i.e., limited to the upper respiratory tract) or no symptoms at all. During a pandemic, especially youngsters will be affected by this evolution as their natural Abs are not yet largely suppressed by a panoply of ‘acquired’, antigen-specific Abs.

Natural Abs, and natural immunity in general, play a critical role in protecting us from pathogens as they constitute our first line of immune defense. In contrast to acquired immunity, innate immune responses protect against a large spectrum of pathogens (so don’t compromise or sacrifice your innate immune defense!). Because natural Abs and innate immune cells recognize a diversified spectrum of foreign (i.e., non-self) agents (only some of which have pathogenic potential), it’s important, indeed, to keep it sufficiently exposed to environmental challenges. By keeping the innate immune system (which, unfortunately, has no memory!) TRAINED, we can much more easily resist germs which have real pathogenic potential. It has, for example, been reported and scientifically proven that exposure to other, quite harmless Coronaviruses causing a ‘common cold ’ can provide protection, although short-lived, against Covid-19 and its loyal henchmen (i.e., the more infectious variants).

Suppression of innate immunity, especially in the younger age groups, can, therefore, become very problematic. There can be no doubt that lack of exposure due to stringent containment measures implemented as of the beginning of the pandemic has not been beneficial to keeping people’s innate immune system well trained. As if this was not already heavily compromising innate immune defense in this population segment, there comes yet another force into play that will dramatically enhance morbidity and mortality rates in the younger age groups: MASS VACCINATION of the ELDERLY. The more extensively the later age group will be vaccinated and hence, protected, the more the virus is forced to continue causing disease in younger age groups. This is only going to be possible provided it escapes to the S-specific Abs that are momentarily raised in previously asymptomatically infected subjects. If the virus manages to do so, it can benefit from the (momentarily) suppressed innate immunity, thereby causing disease in an increasing number of these subjects and ensuring its own propagation. Selecting targeted mutations in the S protein is, therefore, the way to go in order for the virus to enhance its infectiousness in candidates that are prone to getting the disease because of a transient weakness of their innate immune defense.

But in the meantime, we’re also facing a huge problem in vaccinated people as they’re now more and more confronted with infectious variants displaying a type of S protein that is increasingly different from the S edition comprised with the vaccine (the later edition originates from the original, much less infectious strain at the beginning of the pandemic). The more variants become infectious (i.e., as a result of blocking access of the virus to the vaccinated segment of the population), the less vaccinal Abs will protect. Already now, lack of protection is leading to viral shedding and transmission in vaccine recipients who are exposed to these more infectious strains (which, by the way, increasingly dominate the field). This is how we are currently turning vaccines into asymptomatic carriers shedding infectious variants.

At some point, in a likely very near future, it’s going to become more profitable (in term of ‘return on selection investment’) for the virus to just add another few mutations (maybe just one or two) to the S protein of viral variants (already endowed with multiple mutations enhancing infectiousness) in an attempt to further strengthen its binding to the receptor (ACE-2) expressed on the surface of permissive epithelial cells. This will now allow the new variant to outcompete vaccinal Abs for binding to the ACE receptor. This is to say that at this stage, it would only take very few additional targeted mutations within the viral receptor-binding domain to fully resist S-specific anti-Covid-19 Abs, regardless whether the latter are elicited by the vaccine or by natural infecition. At that stage, the virus will, indeed, have managed to gain access to a huge reservoir of subjects who have now become highly susceptible to disease as their S-specific Abs have now become useless in terms of protection but still manage to provide for long-lived suppression of their innate immunity (i.e., natural infection, and especially vaccination, elicit relatively long-lived specific Ab titers). The susceptible reservoir comprises both, vaccinated people and those who’re left with sufficient S-specific Abs due to previous Covid-19 disease).

So, MISSION ACCOMPLISHED for Covid-19 but a DISASTROUS SITUATION for all vaccinated subjects and Covid-19 seropositive people as they’ve now lost both, their acquired and innate immune defense against Covid-19 (while highly infectious strains are circulating!). That’s “one small step for the virus, one giant catastrophe for mankind”, which is to say that we’ll have whipped up the virus in the younger population up to a level that it now takes little effort for Covid-19 to transform into a highly infectious virus that completely ignores both the innate arm of our immune system as well as the adaptive/acquired one (regardless of whether the acquired Abs resulted from vaccination or natural infection). The effort for the virus is now becoming even more negligible given that many vaccine recipients are now exposed to highly infectious viral variants while having received only a single shot of the vaccine.

Hence, they are endowed with Abs that have not yet acquired optimal functionality. There is no need to explain that this is just going to further enhance immune escape. Basically, we’ll very soon be confronted with a super-infectious virus that completely resists our most precious defense mechanism: The human immune system. From all of the above, it’s becoming increasingly difficult to imagine how the consequences of the extensive and erroneous human intervention in this pandemic are not going to wipe out large parts of our human population. One could only think of very few other strategies to achieve the same level of efficiency in turning a relatively harmless virus into a bioweapon of mass destruction. It’s certainly also worth mentioning that mutations in the S protein (i.e., exactly the same protein that is subject to selection of escape mutations) are known to enable Coronaviruses to cross species barriers.

This is to say that the risk that vaccine-mediated immune escape could allow the virus to jump to other animal species, especially industrial livestock (e.g., pig and poultry farms), is not negligible. These species are already known to host several different Coronaviruses and are usually housed in farms with high stocking density. Similar to the situation with influenza virus, these species could then serve as an additional reservoir for SARS-COVID-2 virus. As pathogens have co-evolved with the host immune system, natural pandemics of acute self-limiting viral infections have been shaped such as to take a toll on human lives that is not higher than strictly required. Due to human intervention, the course of this pandemic has been thoroughly disturbed as of the very beginning. Widespread and stringent infection prevention measures combined with mass vaccination campaigns using inadequate vaccines will undoubtedly lead to a situation where the pandemic is getting increasingly ‘out of control’. Paradoxically, the only intervention that could offer a perspective to end this pandemic (other than to let it run its disastrous course) is …VACCINATION.

Of course, the type of vaccines to be used would be completely different of conventional vaccines in that they’re not inducing the usual suspects, i.e., B and T cells, but NK (Natural Killer) cells. There is, indeed, compelling scientific evidence that these cells play a key role in facilitating complete elimination of Covid-19 at an early stage of infection in asymptomatically infected subjects. NK cells are part of the cellular arm of our innate immune system and, like natural Abs, they are capable of recognizing and attacking a broad and diversified spectrum of pathogenic agents. There is a sound scientific rationale to assume that it is possible to ‘prime’ NK cells in ways for them to recognize and kill Coronaviruses at large (include all their variants) at an early stage of infection. NK cells have increasingly been described to be endowed with the capacity to acquire immunological memory. By educating these cells in ways that enable them to durably recognize and target Coronavirus-infected cells, our immune system could be perfectly armed for a targeted attack to the universe of Coronaviruses prior to exposure. As NK cell-based immune defense provides sterilizing immunity and allows for broad spectrum and fast protection, it is reasonable to assume that harnessing our innate immune cells is going to be the only type of human intervention left to halt the dangerous spread of highly infectious Covid-19 variants.

If we, human beings, are committed to perpetuating our species, we have no choice left but to eradicate these highly infectious viral variants. This will, indeed, require large vaccination campaigns. However, NK cell-based vaccines will primarily enable our natural immunity to be better prepared (memory!) and to induce herd immunity (which is exactly the opposite of what current Covid-19 vaccines do as those increasingly turn vaccine recipients into asymptomatic carriers who are shedding virus). So, there is not one second left for gears to be switched and to replace the current killer vaccines by life-saving vaccines. I am appealing to the WHO and all stakeholders involved, no matter their conviction, to immediately declare such action as THE SINGLE MOST IMPORTANT PUBLIC HEALTH EMERGENCY OF INTERNATIONAL CONCERN.

 

Author: Geert Vanden Bossche, DVM, PhD (March 6, 2021) – https://www.linkedin.com/in/geertvandenbossche/